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Risk factors for endometrial cancer in black and white women in the Epidemiology of Endometrial Cancer Consortium (E2C2)

Principal Investigator

Name
Sara Olson

Institution
Memorial Sloan-Kettering Cancer Center

Email
olsons@mskcc.org

About this CDAS Project

Study
PLCO (Learn more about this study)

Project ID
2010-0290

Initial CDAS Request Approval
Feb 2, 2011

Title
Risk factors for endometrial cancer in black and white women in the Epidemiology of Endometrial Cancer Consortium (E2C2)

Summary
Endometrial cancer is the fourth most common cancer in U.S. women. Despite our substantial knowledge of the role of steroid hormones in the etiology of this cancer, relatively little is known about the genetic etiology of this disease or about interactions between genes and exposures. In addition, other important questions about etiology remain unanswered. Little is known about factors that affect prognosis or survival, for which there are large disparities among racial and ethnic groups. In 2006, a group of investigators with special interests in endometrial cancer formed the Epidemiology of Endometrial Cancer Consortium (E2C2). Under the E2C2 consortium, we propose to investigate risk factors for endometrial cancer in black and white women. Although incidence of endometrial cancer is lower in black women than in whites, mortality is considerably higher. While a number of studies have addressed reasons for this large disparity, no clear answer exists. We plan to analyze data on risk factors among non-Hispanic white women and black women. We hypothesize that the strength of association for risk factors will differ between the two groups.

Aims

The specific aim of this study is to investigate risk factors for endometrial cancer in blacks by pooling data on cases and controls from studies in E2C2 that included >10 black cases and >10 black controls. Risk factors to be included are those known or suspected to be associated with risk in white women. For comparison, we will also pool data on risk factors among non-Hispanic white women in the studies that contribute cases and controls for the analysis in blacks. We hypothesize that the strength of association for risk factors will differ between the two groups.

Collaborators

Michele Cote (Karmanos Cancer Institute, Wayne State University)