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Creating a reference distribution of predicted lung cancer risk

Principal Investigator
Name
Scott Lee
Degrees
M.D., Ph.D., M.P.A., M.Phil.
Institution
Vanderbilt University Medical Center
Position Title
Assistant Professor
Email
About this CDAS Project
Study
NLST (Learn more about this study)
Project ID
NLST-763
Initial CDAS Request Approval
Mar 8, 2021
Title
Creating a reference distribution of predicted lung cancer risk
Summary
The purpose of this project is to support a separate study involving non-NLST participants by creating a reference distribution of predicted lung cancer risk. I will calculate baseline predicted lung cancer risk in the NLST sample using the Tammemägi 2012 (PLCOm2012) lung cancer risk prediction model. This distribution will serve as the basis for characterizing participants in the other study as high- or low-risk of lung cancer for their age.
Aims

Aim 1: Calculate predicted lung cancer risk using the Tammemägi 2012 (PLCOm2012) lung cancer risk prediction model. The required variables are: current smoking status; average number of cigarettes smoked per day; duration smoked; age; education; race/ethnicity; body mass index (BMI); current diagnosis of COPD, emphysema, or chronic bronchitis; personal history of cancer; and family history of lung cancer.
Aim 2: Perform quantile regression of predicted lung cancer risk on age to estimate age-specific median risk of lung cancer.
Aim 3: Compare the predicted lung cancer risk of participants in a separate study with the reference median risk of lung cancer in the NLST to estimate study participants' relative risk of lung cancer for their age.

Collaborators

None.