Interactions of lifestyle factors and polygenic risk score in colorectal neoplasm
Principal Investigator
Name
Li Liu
Degrees
M.D., Ph.D.
Institution
Huazhong University of Science and Technology
Position Title
Prof.
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-740
Initial CDAS Request Approval
Mar 9, 2021
Title
Interactions of lifestyle factors and polygenic risk score in colorectal neoplasm
Summary
It is well known that genetic and environmental factors play important roles on carcinogenesis. Previous large-scale genome-wide association studies (GWASs) have identified more than 100 susceptibility loci for colorectal cancer (CRC), and some of them were susceptibility loci for colorectal adenoma (CRA). Then, the combination of these genetic polymorphisms was known as polygenic risk score (PRS). Epidemiological studies have also observed several risk factors for colorectal neoplasm (CRN), such as alcohol consumption, tobacco smoking, red meat consumption etc. However, the interactions between PRS and environmental factors on CRN risk still remains unclear.
Our team have found some gene-environment interaction effects on CRN risk in a multi-center randomized colorectal cancer screening trial which was based on Chinese population. Nevertheless, these findings could not be supported by other existing studies. Considering the limitation, we will use PLCO data and analyzed gene-environment interaction of CRN.
Our team have found some gene-environment interaction effects on CRN risk in a multi-center randomized colorectal cancer screening trial which was based on Chinese population. Nevertheless, these findings could not be supported by other existing studies. Considering the limitation, we will use PLCO data and analyzed gene-environment interaction of CRN.
Aims
1. Analyze gene-environment interaction effects of colorectal neoplasm in PLCO populations.
2. Validate our findings of colorectal neoplasm in PLCO study, which could provide public health strategies for disease prevention.
Collaborators
None.