Study
PLCO
(Learn more about this study)
Project ID
2010-0264
Initial CDAS Request Approval
Sep 27, 2010
Title
Accuracy of colonoscopy self-report
Summary
Epidemiologic studies often rely on patient self-report in determining both the use and results of colonoscopy examination. The validity of these studies is thus dependent on the accuracy of subject recall. Several prior studies have assessed the validity of self-report of the receipt of colonoscopy. However, many fewer studies have reported on patient ability to remember colonoscopy findings (i.e. whether or not polyps were discovered). Further, most studies of the accuracy of colonoscopy self-report have focused on average-risk, screening populations; there is little research addressing this question in those undergoing surveillance following adenoma diagnosis. The study of colonoscopy utilization (SCU), an ancillary study nested within PLCO, provides a unique resource to address the validity of colonoscopy self-report. SCU recruited a broad sample of participants in the PLCO screening arm based on results of the baseline sigmoidoscopy (advanced adenomas, non-advanced adenomas, positive screen with non-adenomatous findings, negative screen, inadequate screen, non-attendance). Subjects were then asked to report their subsequent colonoscopy use and exam findings over a minimum five-year period, through a telephone-administered questionnaire. For all subjects reporting colonoscopies, an attempt was made to verify receipt of the exam and findings using medical records. We propose to evaluate the validity of self-reported information by comparing questionnaire to medical record data.
Aims
We hypothesize that those undergoing surveillance following adenoma diagnosis may have improved recall of subsequent colonoscopies as compared to those without adenomas detected at baseline. We therefore propose to address the following specific aims, both overall and for different groups defined according to the baseline screening results categories (advanced adenomas, non-advanced adenomas, positive screen with non-adenomatous findings, negative screen, inadequate screen, non-attendance). The specific aims relating to the occurrence of subsequent colonoscopies are: To determine how accurately participants report colonoscopy over the follow-up period, and To determine whether any covariates (gender, age, family history, etc.) predict accuracy of colonoscopy self-report. Similarly, the specific aims relating to the outcomes of subsequent colonoscopic exams are: To determine how accurately participants report Colonoscopy findings, i.e. the ability to report whether polyps or, more specifically, adenomas were discovered, and Complications and hospitalizations occurring due to colonoscopy, and To determine whether any covariates (gender, age, family history, etc.) predict accuracy of self-report of colonoscopy outcomes.
Collaborators
Carrie Klabunde (NCI -Health Services and Economics Branch)
