Study
PLCO
(Learn more about this study)
Project ID
2010-0141
Initial CDAS Request Approval
Aug 26, 2010
Title
Utilizing PLCO Prostate Survival Data to predict mortality in chemoprevention studies
Summary
The Prostate Cancer Prevention Trial (PCPT) showed decreased incidence of prostate cancer on the finasteride compared to the placebo arm. However, there was the suggestion of increased incidence of GLeason 7-10 disease and especially of Gleason 8-10 disease. DUe to this, it is unclear whether finasteride would convey a mortality benefit over placebo. PCPT did not follow subjects for mortality. To project mortality in PCPT, one would need survival curves by Gleason status; further, one would need these curves derived from a population that was intensively screened with PSA and DRE, as was the PCPT cohort. The intervention arm of PLCO is such a cohort. In addition to this specific application, providing surivival curves by GLeason status in a highly screened population may also be useful for many other purposes. THerefore, here we display and analyze survival in PLCO by Gleason status (and other variables) and also apply these survival rates to the PCPT cohort to project differential mortality by PCPT arm. We may also do a similar analysis with the REDUCE study data (a comparable study of dutasteride vs placebo).
Aims
1. We plan to present, describe and analyze survival rates by Gleason score categories, study time period, study arm and other factors. THe most intensely screened cohort of cases, i.e., intervention arm cases diagnosed from T0-T5, will be compared with the other groups, within Gleason categories and overall, in terms of survival (prostate cancer specific and overall). 2. The above survival rates will be utilized to estimate mortality from a chemoprevention trial. Specifically, we will apply these survival rates to the incident cases in PCPT in order to estimate relative prostate cancer mortality across PCPT trial arms. We may also do a similar analysis of the REDUCE study data.
Collaborators
Gerald Andriole (Washington Univ)
amanda black (DCEG)
E. David Crawford (Univ. of Colorado)
Robert Grubb (Washington Univ)
Howard Parnes (DCP)
