Summer Han

Ph.D

Stanford University

Assistant Professor

NLST (Learn more about this study)

NLST-732

Dec 8, 2020

Identifying risk factors associated with metastatic progression from non-metastatic primary lung cancer among NLST lung cancer patients

According to the 2009 Surveillance, Epidemiology, and End Results (SEER) data, the 5-year survival rate for lung cancer patients with localized disease at diagnosis is 52%, but the 5-year survival rate for those with distant metastasis at diagnosis is only 3.6%. One of the most common sites of distant metastasis is the brain, among other sites including liver, adrenal glands and bones. Prior studies have shown that out of the non-small cell lung cancer (NSCLC) cases, approximately 10% present with brain metastases at initial diagnosis and 20-50% develop brain metastasis over the course of the disease. Despite high prevalence and low survival of distant metastasis, such as to the brain, little is known about the predictors for metastasis progression from non-metastatic primary lung cancer. Therefore, the goal of this project is to identify risk factors, among demographics, smoking history, nodule characteristics at screening, primary tumor characteristics at diagnosis, family history, medical history, carcinogen exposure history, comorbidities and other clinical factors, and to develop a risk prediction model for metastatic progression from primary lung cancer. The results of this project aim to potentially inform clinical management and metastatic screening at initial primary lung cancer diagnosis.