Dietary inflammatory index and colorectal carcinogenesis: a prospective cohort study
Principal Investigator
Name
Zhuyue Li
Degrees
Ph.D.
Institution
Sichuan University
Position Title
Dr.
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-698
Initial CDAS Request Approval
Dec 2, 2020
Title
Dietary inflammatory index and colorectal carcinogenesis: a prospective cohort study
Summary
As one of the most five commonly cancers, colorectal cancer causes large disease burden. More than 104,000 new cases of colon cancer and 43,340 new cases of rectal cancer were diagnosed in the United States in 2020. Evidence suggests a role for the ability of diet to modulate inflammation in the etiology of this disease. A typical human diet included both proinflammatory and anti-inflammatory foods and nutrients. Therefore, a dietary pattern approach, which provides insights into the complex interactions among dietary components, may guide dietary intervention strategies aimed at the primary prevention of this malignancy. Previously studiy had examined the association between dietary inflammatory index (DII) score and risk of mortality of colorectal cancer patients.
Our current objective is to examine the association between inflammatory potential of diet, as estimated by the DII, and colorectal cancer incidence using data from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial prospective cohort. The PLCO is a well characterized and diverse study population with large number of cancer cases that would provide ample power.
Our current objective is to examine the association between inflammatory potential of diet, as estimated by the DII, and colorectal cancer incidence using data from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial prospective cohort. The PLCO is a well characterized and diverse study population with large number of cancer cases that would provide ample power.
Aims
We aimed to evaluate the associations between dietary inflammatory index and various stages of colorectal carcinogenesis using data from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial prospective cohort.
Collaborators
Kang Wang
Department of the Endocrine and Breast Surgery, The First Affiliated hospital of Chongqing Medical university, Chongqing, PRC