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Principal Investigator
Name
Zhuyue Li
Institution
Sichuan University
Position Title
Dr.
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-692
Initial CDAS Request Approval
Nov 17, 2020
Title
Magnesium intake and colorectal cancer incidence and mortality in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
Summary
As one of the most five commonly cancers, colorectal cancer causes large disease burden. More than 104,000 new cases of colon cancer and 43,340 new cases of rectal cancer were diagnosed in the United States in 2020. Evidence suggests a role for the ability of diet to modulate inflammation in the etiology of this disease. Therefore, a dietary pattern approach, which provides insights into the complex interactions among dietary components, may guide dietary intervention strategies aimed at the primary prevention of this malignancy. Previously studies had examined the association between calcium and vitamin D intake and colorectal cancer incidence. But little has known on magnesium which is deeply interact with calcium and vitamin D.
Our current objective is to examine the association between magnesium intake and colorectal cancer incidence and mortality using data from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial prospective cohort. The PLCO is a well characterized and diverse study population with large number of cancer cases that would provide ample power.
Aims

To examine the association between magnesium intake and colorectal cancer incidence and mortality using data from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial prospective cohort.

Collaborators

Kang Wang
Department of the Endocrine and Breast Surgery, The First Affiliated hospital of Chongqing Medical university, Chongqing, PRC