Evaluate the impact of ovarian cancer interventions for primary prevention, screening and treatment
Principal Investigator
Name
Iakovos Toumazis
Degrees
Ph.D.
Institution
The University of Texas MD Anderson Cancer Center
Position Title
Assistant professor
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-689
Initial CDAS Request Approval
Nov 17, 2020
Title
Evaluate the impact of ovarian cancer interventions for primary prevention, screening and treatment
Summary
This research project aims to model the disease progression of ovarian cancer in the absence of interventions. We will develop a natural history model to simulate the disease progression of ovarian cancer and use it to assess the impact of cancer interventions on ovarian cancer incidence and mortality rates. For the purposes of this project we will investigate the effectiveness and cost-effectiveness of interventions across the ovarian cancer care continuum, from primary preventions to screening to treatment.
Aims
Develop a natural history model for ovarian cancer.
Evaluate the impact of cancer interventions for primary prevention.
Evaluate the impact of ovarian cancer interventions for secondary prevention.
Evaluate the effectiveness and cost-effectiveness of alternative ovarian cancer treatment interventions.
Collaborators
Larissa A. Meyer, The University of Texas MD Anderson Cancer Center
Karen Lu, The University of Texas MD Anderson Cancer Center
Sanjay Shete, The University of Texas MD Anderson Cancer Center
Related Publications
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Development and Validation of a Histology-Specific Natural History Model of Ovarian Cancer.
Ishizawa S, Eghbalizarch M, Nargund RS, Sarayi SMMJ, Niu J, Hemmati M, Tumbarello M, Schaefer AJ, Lu K, Giordano SH, Meyer LA, Toumazis I
Am J Obstet Gynecol. 2025 Jul 4 PUBMED -
Estimating sojourn time and sensitivity of screening for ovarian cancer using a Bayesian framework.
Ishizawa S, Niu J, Tammemagi MC, Irajizad E, Shen Y, Lu KH, Meyer LA, Toumazis I
J Natl Cancer Inst. 2024 Jul 23 PUBMED