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Principal Investigator
Bing Li
Brown University
Position Title
About this CDAS Project
NLST (Learn more about this study)
Project ID
Initial CDAS Request Approval
Sep 20, 2020
Transportation of Diagnostic Accuracy Measures to a New Target Population
When we have estimators from a population where the diagnostic test is evaluated (i.e. source population) but wish to evaluate the test on a different population of interest where the outcome of disease status is missing (i.e. target population), how to interpret and use the source population estimators in the context of target population (i.e. the problem of transportation) needs to be considered. Diagnostic accuracy can be varied with patients' demographics, geographic location, disease severity and etc. If the source population are not representative of the target population, bias occur, i.e. the estimates of test accuracy are not representative of the accuracy in the target population. Our goal is how to transport diagnostic accuracy measures from source population to target population.

1. Develop transportation methods for the area under ROC curve (AUC).
2. Extend the methods to the situation where the marker is missing for target population.
3. Apply the methods to transport AUC from NLST population to National Health and Nutrition Examination Survey (NHANES) population.


Jon Steingrimsson, Brown University
Constantine Gatsonis, Brown University