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Principal Investigator
Name
Kenneth Tang
Degrees
M.S. in Biotechnology
Institution
AIRdx
Position Title
Founder / CEO
Email
About this CDAS Project
Study
NLST (Learn more about this study)
Project ID
NLST-702
Initial CDAS Request Approval
Aug 18, 2020
Title
Development of deep-learning software for the detection, classification, and malignancy risk assessment of lung nodules on LDCT
Summary
Lung cancer is most common cause of cancer death worldwide. Emphasis has been placed on developing guidelines and technologies that promote early detection and diagnosis of lung cancer, with the goal of reducing the mortality rate and improving the chance of survival for patients diagnosed with lung cancer. Over the past decade, numerous governmental agencies and medical societies have published guidelines to promote routine screening of high-risk patients utilizing low-dose computed tomography (LDCT). This has allowed for earlier detection and diagnosis of lung cancer, increasing the overall cure and survival rate. However, the implementation of LDCT screening has also resulted in a greater number of false-positive exams, many of which led to invasive testing, such as subsequent standard CT imaging, biopsy, and occasionally even surgery. Not to mention, radiologists are expected to process, read, and dictate a greater volume of studies a day, which may result in overall reduction in quality of readings and physician burnout.

The goal of this project is to develop a CAD software utilizing CNN algorithms to assist radiologists in the detection, Lung-RADS classification, and malignancy risk assessment of lung nodules on LDCT. This would allow for greater diagnostic confidence amongst radiologists and reduction in false positive findings, subsequently mitigating the risks of lung cancer screening and preventing unnecessary testing.
Aims

- Develop a CNN based CAD software for lung nodule detection, Lung-RADS classification, and malignancy risk assessment
- Evaluate CNN algorithm's accuracy by comparing it to radiologists' diagnostic readings and biopsy results

Collaborators

Pascal Simpkins, AIRdx
Yixiao Zhao, AIRdx
Jinmo Park, AIRdx
Pollyanna Wong, AIRdx