Skip to Main Content

An official website of the United States government

Diet, underlying diseases, reproductive factors and CLL/SLL

Principal Investigator
Name
Huei-Ting Tsai
Institution
NCI, DCEG, GEB
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
2009-0106
Initial CDAS Request Approval
Jun 26, 2009
Title
Diet, underlying diseases, reproductive factors and CLL/SLL
Summary
Chronic lymphocytic leukemia (CLL)/ small lymphocytic lymphoma (SLL) accounts for approximately 30 percent of all leukemia and is the most common form of leukemia among senior adults in western countries. Based on the United States (U.S.) Surveillance, Epidemiology, and End Results (SEER) Registry, the U.S. age-adjusted incidence of CLL is 4 per 100 000 person-years, with an average age at diagnosis of about 70 years. The literature supports a genetic component in CLL development. However, no extrinsic environmental risk factor has been reproducibly identified. We propose to conduct a prospective cohort study in PLCO to evaluate the effects of gender, ethnicity and family history in CLL/SLL. In addition, we will explore diet, underlying disease and reproductive factors in relation to CLL/SLL development. The study findings will advance our understanding about risk factors for CLL/SLL. In addition, based on lymphoma subcommittee suggestions, we will consider expanding our analyses to include follicular lymphoma and other categories of non-Hodgkin lymphoma as appropriate.
Aims

a. To confirm the established effects of sex, ethnicity and family history on risk of CLL/SLL . Male gender, White race, and a familial history of CLL/SLL are established risk factors for CLL/SLL. b. To explore effect of diet, underlying disease and reproductive factors in CLL/SLL. Less fruit or vegetable intake, history of autoimmune or infectious disease and non-pregnancy are possible risk factors for CLL/SLL. BMI is postulated as a possible risk factor as well.

Collaborators

Neil Caporaso (Division of Cancer Epidemiology and Genetics)
Amada Cross (DCEG)
Barry Graubard (DCEG)
Martin Oken (University of Minnesota)

Related Publications