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Principal Investigator
Guo-Chao Zhong Zhong
The Second Affiliated Hospital of Chongqing Medical University
Position Title
About this CDAS Project
PLCO (Learn more about this study)
Project ID
Initial CDAS Request Approval
Jul 24, 2020
Dietary acid load and pancreatic cancer incidence and mortality in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
Despite its relatively low incidence, pancreatic cancer is the third most common cause of cancer-related death in the United States (1). Dietary habits have been found to play a pivotal role in the initiation and progression of pancreatic cancer (2).
Dietary acid load, representing consumption of acidogenic diets characterized by higher dietary intake of proteins and minerals (3, 4), may play an important role in increasing the risk of metabolic abnormalities such as kidney stone formation, chronic kidney disease, loss of lean body mass, hypertension and diabetes mellitus, as well as mortality. Dietary intake can influence the body’s acid–base balance. Acidic pH levels in the extracellular space may enhance the invasive and metastatic potential of cancer cells (5, 6). The general public is being encouraged by the lay press that to prevent cancer, they are persuaded to assess the acidity of their urine and/or saliva as an assessment of the acidity of their body and then to modify their diets accordingly. However, there are no epidemiologic evidence on the association between diet-dependent acid load and risk of pancreatic cancer (7).

To clarify whether higher dietary acid load was associated with higher risks of pancreatic cancer incidence and mortality in the US population.


(1) Kang Wang, affiliation: Department of Endocrine and Breast Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China;
(2) Peng-Fei Yang, affiliation: Department of Nephrology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China