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Principal Investigator
Guo-Chao Zhong
The Second Affiliated Hospital of Chongqing Medical University
Position Title
About this CDAS Project
PLCO (Learn more about this study)
Project ID
Initial CDAS Request Approval
Jul 24, 2020
Low-carbohydrate diets and the risk of pancreatic cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
Pancreatic cancer is the fourth most common cause of cancer-associated mortality in the US population [1]. The etiology of pancreatic cancer remains unclear, but dietary habits have been suggested to play an important role. Observational studies have found that low-carbohydrate diets are associated with increased risks of type 2 diabetes [2], atrial fibrillation [3], and mortality [4]. However, the effects of low-carbohydrate diets on pancreatic cancer remain largely unknown. To our knowledge, only one study in Sweden has investigated the association between low-carbohydrate diets and the risk of pancreatic cancer, with a null association observed. However, whether the results from European population can be extended to other populations needs to be further confirmed.
[1] Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin 2020;70:7-30.
[2] Bao W, Li S, Chavarro JE, Tobias DK, Zhu Y, Hu FB, et al. Low Carbohydrate-Diet Scores and Long-term Risk of Type 2 Diabetes Among Women With a History of Gestational Diabetes Mellitus: A Prospective Cohort Study. Diabetes Care 2016;39:43-9.
[3] Zhang S, Zhuang X, Lin X, Zhong X, Zhou H, Sun X, et al. Low-Carbohydrate Diets and Risk of Incident Atrial Fibrillation: A Prospective Cohort Study. J Am Heart Assoc 2019;8:e011955.
[4] Mazidi M, Katsiki N, Mikhailidis DP, Sattar N, Banach M. Lower carbohydrate diets and all-cause and cause-specific mortality: a population-based cohort study and pooling of prospective studies. Eur Heart J 2019;40:2870-9.

To determine whether low-carbohydrate diets are associated with a reduced risk of pancreatic cancer in a US population.


(1) Kang Wang, affiliation: Department of Endocrine and Breast Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
(2) Jing-Jing Wu, affiliation: Department of Nutrition and Food Hygiene, School of Public Health and Management, Chongqing Medical University, Chongqing, China