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Copper intake and primary liver cancer incidence and survival in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial

Principal Investigator
Name
Yun-Bing Wang
Degrees
ph.D.
Institution
The second affiliated hospital of Chongqing Medical University
Position Title
Dr.
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-649
Initial CDAS Request Approval
Jul 17, 2020
Title
Copper intake and primary liver cancer incidence and survival in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
Summary
Some studies found serum copper level was associated with the incidence of primary liver cancer (PLC), but whether copper intake from diet and supplement was associated with the PLC incidence and survival has not been reported. In our study, we aimed to use the PLCO data to explore the relationship of copper intake and the PLC incidence and survival. Cox regression was employed to calculate hazard ratios for PLC incidence and competing risk regression was employed to calculate subdistribution hazard ratios for PLC survival.
Aims

1. To clarify whether higher copper intake from diet and supplements was associated with lower risks of PLC incidence and mortality in the US population.
2. To provide suggestions for the prevention of primary liver cancer.

Collaborators

1. Guo-Chao Zhong, Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
2. Jian-Ying Zhang, Department of Radiology, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, China.
3. Chun-Mu Miao, Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
4. Long Chen, Department of Hepatobiliary Surgery, Pidu District People's Hospital, Chengdu, Sichuan Province, China.