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A prospective investigation of the relationship between use of non-steroidal anti-inflammatory drugs (NSAIDs) and risk of head and neck cancers (HNC) and malignant melanomas (MM)

Principal Investigator
Name
Amanda Black
Institution
NCI, DCEG, EBP
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
2009-0035
Initial CDAS Request Approval
Jul 23, 2009
Title
A prospective investigation of the relationship between use of non-steroidal anti-inflammatory drugs (NSAIDs) and risk of head and neck cancers (HNC) and malignant melanomas (MM)
Summary
Regular use of non-steroidal anti-inflammatory drugs (NSAIDs) has been associated with a reduced risk of some cancers, particularly colorectal cancer. The few studies that have investigated the association between NSAIDs and head and neck cancers (HNC) (i.e. cancers of the nasopharynx, oropharynx, oral cavity, hypopharynx, and larynx), where smoking and alcohol are the predominant risk factors, are conflicting. While, experimental studies indicate NSAIDs may have a protective effect against malignant melanoma (MM), epidemiological studies investigating are limited. Nevertheless, these findings suggest a potential use of NSAIDs in the prevention, or possibly treatment, of HNC and/or MM. Further studies of the chemo-preventive (and chemo-therapeutic) potential of NSAIDs for these cancers are desirable. Using the baseline and follow-up questionnaire data from the prostate, lung, colorectal and ovarian (PLCO) trial we plan to investigate the relationships between aspirin and other NSAIDs and HNC and MM.
Aims

1. To investigate the association between aspirin and other NSAID use and HNC. We hypothesize that aspirin and other NSAID use will be associated with a reduced risk of these cancers. 2. To investigate the association between aspirin and other NSAID use and the risk of MM. We hypothesize that aspirin and other NSAID use will be associated with a reduced risk of MM.

Collaborators

Carmel Hughes (Queen's University Belfast)
Jessica Wilson (Queen's University Belfast)
Lesley Anderson (Queen's University Belfast)
Liam Murray (Queen's University Belfast)

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