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Detailed Analysis from Repeated PSA Screening for Prostate Cancer from the T0-T3 Study Years

Principal Investigator
Name
Douglas Reding
Institution
Marshfield Clinic Foundation
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
2006-0033
Initial CDAS Request Approval
Jul 1, 2006
Title
Detailed Analysis from Repeated PSA Screening for Prostate Cancer from the T0-T3 Study Years
Summary
PSA and DRE data from the baseline screening round and from the subsequent 3 follow-up rounds are being summarized in the T0-T3 manuscript. However, space limitations have prevented a full analysis of the patterns of PSA and DRE results through the first 4 screening rounds. This study is designed to focus on the patterns of PSA and DRE screening in a longitudinal fashion and their effects on subsequent screening behavior and cancer detection.
Aims

This study aims to examine PSA and DRE screening results as a function of time or serial screening. The PLCO study has previously reported the results of the baseline screening round. However, the expansion of the screening results through 3 subsequent screening rounds (T1-T3) increases the complexity of the patterns of PSA data and their relationship to DRE status also measured longitudinally. In this study we propose as null hypotheses: 1. PSA results are unaffected by DRE status during serial screening 2. PSA positivity and changes in PSA status (positive/negative) do not affect the probability that a subject has cancer. 3. PSA and DRE status during serial screening do not affect cancer outcomes such as grade and stage. We propose to examine these hypotheses by examining in detail the available data on patient characteristics, PSA and DRE status and cancer status during the first four screening rounds of the PLCO Cancer Screening trial.

Collaborators

Amanda Black (Division of Cancer Prevention)
Robert Grubb (Washington University)
Catherine McCarty (Marshfield Clinic Research Foundation) - Current Lead Investigator (3/4/2013)