Drinking and pre-diagnosed BMI trajectories and their impact on the mortality of upper-gastrointestinal cancers in the PLCO population.
Principal Investigator
Name
Jianjun Li
Degrees
Ph.D./M.D.
Institution
Sun Yat-Sen University Caner Center
Position Title
Professor
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-546
Initial CDAS Request Approval
Nov 13, 2019
Title
Drinking and pre-diagnosed BMI trajectories and their impact on the mortality of upper-gastrointestinal cancers in the PLCO population.
Summary
Upper-gastrointestinal（Upper GI）cancers，including esophageal and gastric carcinomas are highly lethal malignancies that have been ranked among the top 10 most frequent cancers and leading causes of cancer-related mortality. Alcohol drinking and obesity, two major global health challenges, are commonly reported risk factors for Upper GI cancers. Alcohol is a major risk factor for esophageal squamous cell carcinoma (ESCC), the most prevalent histological subtype of esophageal cancer worldwide. Pandeya et al. reported alcohol intake greater than 170 g/wk, possess a significant linear effect with ESCC(OR, 1.03; 95% CI, 1.02-1.05 per 10 g alcohol/wk). It is reported that adult weight gain is associated with several types of cancers including esophageal and gastric cancer. Du et al. reported higher waist circumference(WC)and waist to hip ratio (WHR) were significantly associated with increased risk of total gastroesophageal cancer (WC: RR 1.68, 95% CI: 1.38, 2.04; WHR: RR 1.49, 95% CI: 1.19, 1.88).
Although the association between drinking and body weight gain on Upper GI incidence had been established, it is still unclear the extent to which drinking behaviors (e.g. drinking cessation, drinking intensity, duration, frequency) and body weight gain would affect Upper GI patients’ mortality. Moreover, how change in drinking behaviors and pre-diagnosed BMI on the mortality from Upper GI cancers is not investigated yet. In this study, we will estimate the impacts of change in drinking behaviors and pre-diagnosed BMI on the mortality from Upper GI cancers. The findings may provide the evidences for physicians to effectively motivate and teach their participants to reduce existing risk behaviors and improve their lifestyle.
Although the association between drinking and body weight gain on Upper GI incidence had been established, it is still unclear the extent to which drinking behaviors (e.g. drinking cessation, drinking intensity, duration, frequency) and body weight gain would affect Upper GI patients’ mortality. Moreover, how change in drinking behaviors and pre-diagnosed BMI on the mortality from Upper GI cancers is not investigated yet. In this study, we will estimate the impacts of change in drinking behaviors and pre-diagnosed BMI on the mortality from Upper GI cancers. The findings may provide the evidences for physicians to effectively motivate and teach their participants to reduce existing risk behaviors and improve their lifestyle.
Aims
The PLCO data are needed to conduct following specific aims:
1) to determine the impact of changes in drinking behaviors on Upper GI patients’ mortality.
2) to estimate the association between weight changes before cancer diagnosis and Upper GI patients’ mortality.
Collaborators
Chuan-Bo Xie，Sun Yat-Sen University Cancer Center