Genome-wide Association Study of Adenoma Risk in the PLCO Trial
Principal Investigator
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
2008-0035
Initial CDAS Request Approval
Nov 10, 2008
Title
Genome-wide Association Study of Adenoma Risk in the PLCO Trial
Summary
Colorectal adenoma is an established precursor to colorectal cancer. Although several genome-wide association studies (GWAS) have identified genetic loci associated with colorectal cancer risk, no GWAS have been conducted to specifically examine adenoma risk. Given the importance of adenoma in the development of colorectal cancer and in early detection, we propose to conduct an in silico meta-analysis of GWAS of adenoma using data from 900 to 1200 cases of colorectal adenoma and more than 1500 screen-negative control subjects for whom 550K SNPs or more have been genotyped. The top 96 hits from the combined meta-analysis will then been replicated in an additional 2000 colorectal adenoma cases and 2000 controls (PLCO EEMS study 2007-008). This study is powered to identify the SNPs most strongly associated with colorectal adenoma and can form the basis for larger studies
Aims
The specific aims of this study are to: 1) conduct an in silico GWAS of adenoma risk using GWAS data generated as part of three PLCO-based studies (CGEMS, PanScan, and GEI lung); 2) conduct a meta-analysis of the GWAS results from PLCO and other study populations, including NHS and possibly other studies; 3) replicate the top hits from the adenoma GWAS meta-analysis. (Aim 3 has already been approved under PLCO EEMS Study 2007-008.)
Collaborators
Sonja Berndt (DCEG)
David Hunter (Harvard)
Richard Hayes (DCEG)