(Learn more about this study)
Initial CDAS Request Approval
Sep 26, 2008
Lung Cancer Risk Prediction – A Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial Study
Lung cancer is the leading cause of cancer death in the developed world. Being able to identifying individuals a high risk for lung cancer is important for several reasons. Individuals identified to be at higher risk might be motivated to quit smoking if they are current smokers or might be targeted for more intensive smoking cessation programs. High risk individuals might benefit from lung cancer chemoprevention or screening programs. Lung cancer chemoprevention or screening trials efficiency may increase if they were able to enroll high risk individuals. To date several models have been developed to predict lung cancer risk: (1-6). However, current models have several limitations: (1) They incorporate only a limited number of potentially useful predictors. (2) Their overall predictive performance is generally low. (3) Some of these models were based on suboptimal study designs and the models and estimates may be biased. (4) Some studies have used suboptimal analytic approaches. The aim or the proposed study is to develop and validate a comprehensive and improved lung cancer prediction model. The study plans to use data from the screening arm of the PLCO trial to develop and validate a lung cancer risk prediction model using logistic and Cox proportional hazard regressions. Cumulative incidence of lung cancer will be estimated in the presence of competing causes of mortality. A random sample of half of the PLCO screenees will be used to develop the model and the remaining half will serve as a validation set. Calibration and discriminatory power of models will be evaluated by computing the ratio of expected number to observed number of lung cancer cases along with confidence intervals, and by the receiver operator characteristic area under the curve (ROC AUC) for logistic regression models and the equivalent concordance index (syn., c-statistic) for Cox models, respectively.
The study aims are (1) to identify new predictors of lung cancer risk not previously included in lung cancer risk prediction models, and (2) to develop and validate an improved lung cancer risk prediction model.
Martin Tammemagi (Dept. Community Health Sciences, Brock University / Henry Ford Health System)
Lung cancer risk prediction: Prostate, Lung, Colorectal And Ovarian Cancer Screening Trial models and validation.
Tammemagi CM, Pinsky PF, Caporaso NE, Kvale PA, Hocking WG, Church TR, Riley TL, Commins J, Oken MM, Berg CD, Prorok PC
J. Natl. Cancer Inst.
2011 Jul; Volume 103 (Issue 13): Pages 1058-68
Prediction of true positive lung cancers in individuals with abnormal suspicious chest radiographs: a prostate, lung, colorectal, and ovarian cancer screening trial study.
Tammemagi MC, Freedman MT, Pinsky PF, Oken MM, Hu P, Riley TL, Ragard LR, Berg CD, Prorok PC
J Thorac Oncol
. 2009 Jun; Volume 4 (Issue 6): Pages 710-21