Whole grains and dietary fiber and the risk of pancreatic cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
Principal Investigator
Name
Guo-Chao Zhong
Degrees
Ph.D.
Institution
The Second Affiliated Hospital of Chongqing Medical University
Position Title
Dr.
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-510
Initial CDAS Request Approval
Aug 23, 2019
Title
Whole grains and dietary fiber and the risk of pancreatic cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
Summary
A number of case-control studies have found that intake of whole grains and dietary fiber is associated with a reduced risk of pancreatic cancer (1, 2). However, case-control studies are subject to recall bias and have an inability to establish a temporal association. A 2002 prospective study of diet and pancreatic cancer in male smokers showed that intake of dietary fiber or wheat products was not associated with the risk of pancreatic cancer (3). However, these findings in male smokers may be not generalizable to other populations. Recently, an analysis of ΕPIC-Norfolk study data also revealed a null association between dietary fiber and the risk of pancreatic cancer (4). Of note, these two prospective studies only included a small number of pancreatic cancer cases, with 163 cases in the first study and 88 cases in the latter study. Thus, their insignificant associations may result from the insufficient power due to the limited number of pancreatic cancer cases. With the above-mentioned considerations in mind, our research group decided to examine the association between whole grains and dietary fiber and the risk of pancreatic cancer using data from Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial.
References:
1. Lei Q, Zheng H, Bi J, Wang X, Jiang T, Gao X et al. Whole Grain Intake Reduces Pancreatic Cancer Risk: A Meta-Analysis of Observational Studies. Medicine 2016; 95(9): e2747; e-pub ahead of print 2016/03/06; doi 10.1097/md.0000000000002747.
2. Wang CH, Qiao C, Wang RC, Zhou WP. Dietary fiber intake and pancreatic cancer risk: a meta-analysis of epidemiologic studies. Scientific reports 2015; 5: 10834; e-pub ahead of print 2015/06/04; doi 10.1038/srep10834.
3. Stolzenberg-Solomon RZ, Pietinen P, Taylor PR, Virtamo J, Albanes D. Prospective study of diet and pancreatic cancer in male smokers. American journal of epidemiology 2002; 155(9): 783-792; e-pub ahead of print 2002/04/30; doi 10.1093/aje/155.9.783.
4. Koulouris, A. I. Luben, R. Banim, P. et al. Dietary Fiber and the Risk of Pancreatic Cancer. Pancreas. 2019 Jan;48(1):121-125.
References:
1. Lei Q, Zheng H, Bi J, Wang X, Jiang T, Gao X et al. Whole Grain Intake Reduces Pancreatic Cancer Risk: A Meta-Analysis of Observational Studies. Medicine 2016; 95(9): e2747; e-pub ahead of print 2016/03/06; doi 10.1097/md.0000000000002747.
2. Wang CH, Qiao C, Wang RC, Zhou WP. Dietary fiber intake and pancreatic cancer risk: a meta-analysis of epidemiologic studies. Scientific reports 2015; 5: 10834; e-pub ahead of print 2015/06/04; doi 10.1038/srep10834.
3. Stolzenberg-Solomon RZ, Pietinen P, Taylor PR, Virtamo J, Albanes D. Prospective study of diet and pancreatic cancer in male smokers. American journal of epidemiology 2002; 155(9): 783-792; e-pub ahead of print 2002/04/30; doi 10.1093/aje/155.9.783.
4. Koulouris, A. I. Luben, R. Banim, P. et al. Dietary Fiber and the Risk of Pancreatic Cancer. Pancreas. 2019 Jan;48(1):121-125.
Aims
1. Investigate the association of whole grains and dietary fiber with risk of pancreatic cancer using Cox proportional hazard modeling.
2. Investigate if the association of whole grains and dietary fiber with risk of pancreatic cancer is modified by age, sex, body mass index, type 2 diabetes, smoking, and alcohol.
Collaborators
(1) Jian-Ping Gong, Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University;
(2) You-Qi-Le Wu, Department of Nutrition and Food Hygiene, School of Public Health and Management, Chongqing Medical University, Chongqing, China;
(3) Kang Wang,Department of Breast and Endocrine Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China