Predictors of Vitamin D status (as measured by 25(OH)D in serum) : in particular BMI, Exercise and Dietary intake and Season
Principal Investigator
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
2008-0018
Initial CDAS Request Approval
Jun 20, 2008
Title
Predictors of Vitamin D status (as measured by 25(OH)D in serum) : in particular BMI, Exercise and Dietary intake and Season
Summary
There are two requirements for adequate vitamin D status to be maintained when there is seasonal variation in vitamin D input. One of these is for the skin to receive sufficient exposure to solar UV light in summer, to raise the reserves of 25(OH)D. The second requirement is for an efficient mechanism to allow 25(OH)D reserves to be available during the months of winter. Our overall hypothesis is that exercise is an independent risk factor for vitamin D status and is particularly important in the winter months, independent of BMI and dietary intake of vitamin D. The strategy that will be followed to test this proposal will be an investigation of the influence of physical exercise, dietary vitamin D and BMI on the maintenance of vitamin D status (i.e., 25(OH)D levels) in a non elderly human population (PLCO cohort) along with known confounders.
Aims
The specific aim of this proposal is to investigate predictors of vitamin D status in humans in particular the specific aim is to investigate the the relationship between
1. Exercise and 25(OH)D levels
2. BMI and 25(OH)D levels
3. Dietary vitamin D sources and 25(OH)D
Collaborators
David Fraser (DCEG, NCI)
Wen-Yi Huang (University of Sydney, Australia)
Kaye Brock (University of Sydney, Australia)
Rebecca Mason (University of Sydney, Australia)
Related Publications
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Diabetes prevalence is associated with serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in US middle-aged Caucasian men and women: a cross-sectional analysis within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial.
Brock KE, Huang WY, Fraser DR, Ke L, Tseng M, Mason RS, Stolzenberg-Solomon RZ, Freedman DM, Ahn J, Peters U, McCarty C, Hollis BW, Ziegler RG, Purdue MP, Graubard BI
Br. J. Nutr. 2011 Aug; Volume 106 (Issue 3): Pages 339-44 PUBMED -
Low vitamin D status is associated with physical inactivity, obesity and low vitamin D intake in a large US sample of healthy middle-aged men and women.
Brock K, Huang WY, Fraser DR, Ke L, Tseng M, Stolzenberg-Solomon R, Peters U, Ahn J, Purdue M, Mason RS, McCarty C, Ziegler RG, Graubard B
J. Steroid Biochem. Mol. Biol. 2010 Jul; Volume 121 (Issue 1-2): Pages 462-6 PUBMED