Skip to Main Content

An official website of the United States government

Pooling Project of Prospective Studies of Diet and Cancer: Advanced Prostate Cancer

Principal Investigator
Name
Regina Ziegler
Institution
NCI, DCEG, EBP
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
2008-0048
Initial CDAS Request Approval
Feb 5, 2009
Title
Pooling Project of Prospective Studies of Diet and Cancer: Advanced Prostate Cancer
Summary
This proposal focuses on evaluating the relationship between dietary factors and risk of advanced prostate cancer in the Pooling Project of Prospective Studies of Diet and Cancer. Other proposals not considered here are planned with respect to glioma and ER- prostate cancer. Both exposure and covariate definitions will be standardized across studies in all analyses. Evaluation of these associations has substantial public health significance since advanced prostate cancers have high case fatality rates. Identifying ways to prevent the occurrence of these cancers through lifestyle factors such as diet represents an important public health strategy. Most studies have used the case control design, which is more susceptible to recall and selection bias than prospective cohort studies. The Pooling Project will include over 5,500 cases of advanced prostate cancer. The increased statistical power gained from combining data from the multiple cohort studies enables the examination of associations within population subgroups (such as older age groups, smokers, non-users of supplements, and individuals with low intakes of a particular nutrient such as folate, vitamin C, or vitamin E) which may potentially identify high risk groups. These analyses should contribute to identifying lifestyle behaviors for preventing these diseases.
Aims

This proposal, in the Pooling Project of Prospective Studies of Diet and Cancer (referred to as the Pooling Project) will examine associations between dietary factors and risk of advanced prostate cancer. We will evaluate the following hypotheses for advanced prostate cancer in the 14 studies that include men: 1. High dairy, milk, and calcium intakes increase the risk of advanced prostate cancer; vitamin D intake decreases advanced prostate cancer risk. High retinol intake attenuates the decreased risk with vitamin D. 2. Red meat, particularly processed meat, and animal fat intakes are positively associated with the risk of advanced prostate cancer; total fat intake is not associated with the risk of advanced prostate cancer; and fish and marine omega-3 (n3) fatty acid intakes are inversely associated with the risk of advanced prostate cancer. 3. Total fruit and vegetable and total vegetable intakes are not associated with the risk of advanced prostate cancer. Cruciferous vegetable and tomato/tomato product intakes are inversely associated with the risk of advanced prostate cancer, particularly among older men. 4. An inverse association between vitamin E intake and advanced prostate cancer risk is modified by smoking status such that vitamin E intake is associated with a reduced risk among smokers only. 5. Body mass index is positively associated with the risk of advanced prostate cancer, particularly for men over age 65.

Collaborators

Stephanie Smith-Warner (Harvard)
Jiyoung Ahn (NEB, DCEG)
Sonja Berndt (OEEB, DCEG)
Richard Hayes (OEEB, DCEG)

Related Publications