(Learn more about this study)
Initial CDAS Request Approval
Jun 20, 2008
Study of Genetic Determinants of Serum Nutrients
Existing studies support heritable components to serum nutritional status, and the latter biochemical phenotypes have been related to cancer and other chronic disease risk. The genetic basis for these serum micronutrient phenotypes is, however, complex and not well understood, although candidate gene and linkage studies have identified a limited number of genetic polymorphisms that account for some of the population variance. This nutrition-based project seeks to identify genetic markers through the inherent agnostic GWAS approach for the CGEMS serologic nutrient phenotypes including vitamins D and E, selenium, one-carbon nutrients, carotenoids, and retinol. Through this investigation, NEB aims to improve our understanding of the determinants of these nutrient and dietary exposures and their associations with cancer etiology.
We will examine genome-wide predictors of nutrient biochemical status (e.g., 25-hydroxy-vitaminD, alpha-tocopherol, retinol, and lycopene) in the CGEMS prostate set. Results from the PLCO GWAS will then be pooled with those from the ATBC and NHS studies in a pooled analysis. Any interesting findings will be replicated within other Harvard and /or DCEG cohorts, and a separate GRC proposal will be submitted for any replicate genotyping.
Jiyoung Ahn (DCEG)
Sonja Berndt (DCEG)
Demetrius Albanes (DCEG)
Richard Hayes (DCEG)
Ulrike Peters (Fred Hutchinson Cancer Research Center)