Occurrence and Natural History of Complex Ovarian Cysts in PLCO

Principal Investigator

Name
Bruce Kessel

Institution
Pacific Health Research Institute (Hawaii)

Email
bkessel@queens.org

About this CDAS Project

Study
PLCO (Learn more about this study)

Project ID
2008-0076

Initial CDAS Request Approval
Feb 5, 2009

Title
Occurrence and Natural History of Complex Ovarian Cysts in PLCO

Summary
Comparable to the recently completed work describing the incidence, prevalence, and natural history of simple ovarian cysts in PLCO (Greenlee 2008), this work will leverage the large size and regimented TVU screening of the PLCO trial to evaluate and comment on the occurrence, natural history, and relation to ovarian cancer, if any, of complex ovarian cysts among post-menopausal women. Also similar to the simple cyst project, this work will be a natural followup to the work of Hartge and colleagues (2000), which provided a description of the occurrence of simple and complex ovarian cysts at the T0 screening, and found no association of baseline cyst prevalence with recognized ovarian cancer risk factors.

Aims

The specific aims of this project are to describe: 1) the prevalence of complex ovarian cysts at a woman's first screening where the ovaries were visualized; 2) the incidence of complex ovarian cysts at subsequent screenings among women previously free of complex cysts; 3) the progression or regression of identified complex cysts over time; and, 4) the potential association with subsequent ovarian cancer development.

Collaborators

Bruce Kessel (Pacific Health Research Institute; John A Burns School of Medicine, U. Hawaii)
Trisha Hartge (DCEG, NCI)
Doug Reding (Marshfield Clinic Research Foundation)