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Comparison of the efficacy of sigmoidoscopy in screening coloretal cancer among high-risk and average-risk populations

Principal Investigator
Name
Rui-Hua Xu
Degrees
M.D., Ph.D.
Institution
Sun Yat-Sen University Cancer Center
Position Title
Professor
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-459
Initial CDAS Request Approval
Mar 25, 2019
Title
Comparison of the efficacy of sigmoidoscopy in screening coloretal cancer among high-risk and average-risk populations
Summary
Colorectal cancer (CRC) is the second most common cancer in men and the third in women. Screening for CRC allows earlier detection of precancer lesions, timely treatments, and improved quality of life. The U.S. Preventive Services Task Force recommends a sigmoidoscopy every five years combined with a midinterval sensitive FOBT for residents aged 50 to 75 years. However, it did not recommend individualized screening strategies for high-risk group and average-risk group populations by incorporating the balance of benefits and potential harms. We aim to examine the pros and cons of current screening strategies for average-risk group from health economic perspective . Therefore, we are applying for data from the PLCO database, including the colorectal dataset, dietary, the Supplemental Questionnaire, SCU data and contamination survey, to compare the tumor diagnostic rate, including polyps and CRC, between high-risk group and average-risk group.
Aims

Compare the age at diagnosis between the intervention arm and the control arm to explore the optimal age for sigmoidoscopy/ colocoscopy screening.
Compare the total diagnostic rate and screening efficiency between high-risk group and average-risk group in the intervention arm.
Compare the diagnostic rate of T3 screening and T5 screening for high-risk group and average-risk group in the intervention arm and clarify the most appropriate screening age periods for these two groups.
To explore the optimal screening intervals for average risk population and high risk population from the health economic perspective.

Collaborators

Chuan-Bo Xie，Sun Yat-Sen University Cancer Center

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