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Race-ethnicity, socioeconomic status and the yield of screening flexible sigmoidoscopy

Principal Investigator
Name
Adeyinka Laiyemo
Institution
NCI, DCP, BRG
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
2007-0058
Initial CDAS Request Approval
Dec 21, 2007
Title
Race-ethnicity, socioeconomic status and the yield of screening flexible sigmoidoscopy
Summary
There is evidence of disparity in colorectal cancer (CRC) incidence and survival based on race/ethnicity and socioeconomic status (SES). l Differences in prevalence of risk factors and use of preventive services are believed to be important contributors to race/SES differences in cancer incidence and mortality l Low SES is associated with less CRC screening even in a universal healthcare environment l Compared to Whites, Blacks are more likely and Asians are less likely to: Have proximal adenomas with advanced pathological features; have proximal tumors; present with CRC at an earlier age and be diagnosed at an advanced stage of disease. However, previous studies are limited by retrospective design; non screening population; single institution experience; small sample size and lack of histopathologic information
Aims

l To assess the separate and joint effects of race and SES on the yield of adenoma detection l at baseline flexible sigmoidoscopy (FSG) (prevalence) l at year 3 and year 5 FSG (incidence) l To investigate racial/SES differences in the distribution and histologic characteristics of adenomas and l To evaluate the prevalence of advanced pathology in small polyps as a potential cause for CRC disparity. This has not been investigated in previous studies.

Collaborators

Chyke A. Doubeni (University of Massachusetts Medical School)
Pam Marcus (Division of Cancer Prevention)
Paul Pinsky (Division of Cancer Prevention)

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