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One carbon nutritional factors and pancreatic cancer risk

Principal Investigator
Name
Rachael Stolzenberg-Solomon
Institution
NCI, DCEG, NEB
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
2007-0057
Initial CDAS Request Approval
Feb 15, 2007
Title
One carbon nutritional factors and pancreatic cancer risk
Summary
Limited studies have examined the association between one-carbon nutrients and pancreatic cancer. The proposed study will follow-up this previous studies by examining the association between dietary one-carbon nutrients and their food sources with the risk of pancreatic cancer prospectively in the Prostate, Lung, Ovarian, and Colorectal Cancer Screening Trial (PLCO) cohort. The dietary factors that will be examined include food, supplemental and combined total intake of folate, vitamins, B6, and B12, methionine, as well as the primary food contributors of these nutrients, and antagonists to one-carbon metabolism, namely alcohol consumption and cigarette smoking. The analysis will consider both follow-up and calendar time interactions in order to examine the effects of the mandatory folic acid fortification in the United States that occurred in 1998.
Aims

The primary aims of this study are: 1) To examine the association between dietary factors related to one-carbon metabolism and pancreatic cancer risk in the PLCO trial. Specifically we will examine dietary, supplemental, and combined total folate, vitamin B6, methionine, and alcohol in relation to pancreatic cancer. We hypothesize that dietary folate will be inversely associated with pancreatic cancer; however supplemental folic acid will be positively associated with pancreatic cancer; however, we will not observe an association between the other one-carbon nutritional factors and pancreatic cancer. 2) To examine the association between the major food contributors to the one carbon nutrient and pancreatic cancer. We hypothesize that we will not observe associations between the top food sources of the one carbon nutrients and pancreatic cancer. The secondary aim of this study is: 1) To examine whether the association between the dietary factors are modified by one carbon agonists, namely smoking and alcohol use. We hypothesize that alcohol and smoking will modify the association between dietary folate and folic acid; however no interaction will be observed for the other one carbon nutrients.

Collaborators

Kevin Dodd (NCI/PLCO)
Cari Meinhold (NEB/DCEG/NCI)
Brietta Oaks (NCI/PLCO)

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