Wen-Yi Huang

NCI, DCEG, OEEB

PLCO (Learn more about this study)

2007-0045

Oct 15, 2007

Interrelationship between Sexually Transmitted Infections, Genetic Variation in MSR1 and Other Inflammation Genes, and Prostate Cancer (CGEMS Value-Added Study)

Supporting findings from meta-analyses of case-control studies (11;12) and preliminary analysis in the PLCO (Huang et al, AACR 2007) suggest that sexually transmitted infections (STIs) may account for a subset of prostate cancer. The macrophage scavenger receptor 1 (MSR1) gene on chromosome 8p22 has been identified as a candidate gene for prostate cancer by multiple approaches (13-15), including preliminary results from the PLCO Cancer Genetic Markers of Susceptibility (CGEMS) scan (https://caintegrator.nci.nih.gov/cgems/ or Appendix Table 1A). MSR1 encodes a homotrimeric class A scavenger receptor that binds a wide range of ligands, including gram-negative (e.g., N. gonorrhea and Chlamydia trachomatis) and gram-positive organisms, and participates in innate and adaptive immunity against infection, inflammation, and other biological processes (1;2). Evidence from in vitro and in vivo studies showed that MSR1 may contribute to hosts' defense against infection (3-6), suppression of excessive inflammatory responses during infection (7;8), and correspondingly, reduced susceptibility to prostate cancer (9;10). The interrelationship between STIs, genetic variants in MSR1 and other inflammation genes, and prostate cancer has not been investigated in epidemiologic studies. We request the covariate and CGEMS data from the PLCO to evaluate the following specific aims: