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Genetic Determinants of Height and BMI in the PLCO Trial and Collaborating Studies

Principal Investigator
Name
Sonja Berndt
Institution
NCI, DCEG, OEEB
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
2007-0038
Initial CDAS Request Approval
Jun 12, 2007
Title
Genetic Determinants of Height and BMI in the PLCO Trial and Collaborating Studies
Summary
Background and Purpose: Obesity is associated with increased risks for all-cause mortality and several specific cancer types. Preliminary data from the PLCO Trial show excess risks for the obese (BMI, 30 + vs. 18.5-25.0) for all-causes mortality (HR = 1.9; 95%CI: 1.8-2.0) and for cancers at specific sites (colon cancer, endometrial cancer, non-lymphoid hematopoietic malignancies, AML, esophageal adenocarcinoma, stomach cancer, liver and intrahepatic bile duct cancer). Risks tend to increase linearly with increasing weight beyond the normal range (BMI, 18.5-25.0). With increasing obesity in the U.S. population, it is urgent that the environmental and genetic determinants of this condition are identified. Several research teams are doing genome wide scans in cancer, diabetes and other diseases, in population series for which standard anthropometric data have been collected (recent height and weight, at a minimum). We propose a collaborative effort, combining data across multiple genome-wide scans to identify and verify SNP associations with height and BMI (i.e., weight independent of height).
Collaborators

Sonja Berndt (NCI)
Stephen Chanock (NCI)
Wen-Yi Huang (NCI)

Related Publications
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    Nat. Genet. 2014 Nov; Volume 46 (Issue 11): Pages 1173-86 PUBMED
  • Association between class III obesity (BMI of 40-59 kg/m2) and mortality: a pooled analysis of 20 prospective studies.
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    PLoS Med. 2014 Jul; Volume 11 (Issue 7): Pages e1001673 PUBMED
  • Body mass index and risk of death in Asian Americans.
    Park Y, Wang S, Kitahara CM, Moore SC, Berrington de Gonzalez A, Bernstein L, Chang ET, Flint AJ, Freedman DM, Gaziano JM, Hoover RN, Linet MS, Purdue M, Robien K, Schairer C, Sesso HD, White E, Willcox BJ, Thun MJ, Hartge P, ...show more Willett WC
    Am J Public Health. 2014 Mar; Volume 104 (Issue 3): Pages 520-5 PUBMED
  • Meta-analysis of gene-level associations for rare variants based on single-variant statistics.
    Hu YJ, Berndt SI, Gustafsson S, Ganna A, Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Hirschhorn J, North KE, Ingelsson E, Lin DY
    Am. J. Hum. Genet. 2013 Aug; Volume 93 (Issue 2): Pages 236-48 PUBMED
  • A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
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  • Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
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    PLoS Genet. 2013 Jun; Volume 9 (Issue 6): Pages e1003500 PUBMED
  • FTO genotype is associated with phenotypic variability of body mass index.
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    Nature. 2012 Oct; Volume 490 (Issue 7419): Pages 267-72 PUBMED
  • Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
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  • Hundreds of variants clustered in genomic loci and biological pathways affect human height.
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    Nature. 2010 Oct; Volume 467 (Issue 7317): Pages 832-8 PUBMED