The role of environmental and socioeconomic factors in urologic malignancies
Principal Investigator
Name
Bashir Al Hussein
Degrees
MD
Institution
New York Presbyterian Hospital
Position Title
Urology Resident
Email
About this CDAS Project
Study
NLST
(Learn more about this study)
Project ID
NLST-446
Initial CDAS Request Approval
Oct 16, 2018
Title
The role of environmental and socioeconomic factors in urologic malignancies
Summary
Prostate cancer is the second most diagnosed cancer among men, with an estimated 1.1 million new cases diagnosed in 2012 and third most common cause of cancer death among men. Smoking tobacco has been suggested to be associated with poor prognosis in men diagnosed with prostate cancer. Similarly, smoking has been linked to renal cell carcinoma and is associated with worse prognosis. Whereas, bladder cancer and smoking have a well established association.
The role of environmental and socioeconomic factors in urologic malignancies has been previously studied. Understanding such relationships will identify modifiable risk factors that will allow us to identify certain populations that are at a higher risk. For instance obesity has been found to be associated with increasing incidence of renal cell carcinoma, whereas rubber production and dye production industries have been associated with bladder cancer. Therefore, it is critical to utilize established comprehensive datasets to validate and further identify the factors associated with mortality from urologic malignancies.
Given that the National Lung Screening Trial dataset has excellent smoking information, environmental and socioeconomic data; we will aim to use this comprehensive dataset to assess the impact of smoking on bladder, prostate and kidney cancer. In addition, establish if certain occupations and socioeconomic status are associated with worse disease outcomes.
The role of environmental and socioeconomic factors in urologic malignancies has been previously studied. Understanding such relationships will identify modifiable risk factors that will allow us to identify certain populations that are at a higher risk. For instance obesity has been found to be associated with increasing incidence of renal cell carcinoma, whereas rubber production and dye production industries have been associated with bladder cancer. Therefore, it is critical to utilize established comprehensive datasets to validate and further identify the factors associated with mortality from urologic malignancies.
Given that the National Lung Screening Trial dataset has excellent smoking information, environmental and socioeconomic data; we will aim to use this comprehensive dataset to assess the impact of smoking on bladder, prostate and kidney cancer. In addition, establish if certain occupations and socioeconomic status are associated with worse disease outcomes.
Aims
1- Assess the incidence of bladder, kidney, and prostate cancer deaths in the NLST cohort.
2- Assess the correlation between smoking and the quantity of smoking with urologic malignancies; bladder, kidney and prostate cancer
3- Determine the impact of demographic, environmental and socioeconomic factors on mortality from urologic malignancies
Collaborators
Jonathan Fainberg - New York Presbyterian Hospital