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Principal Investigator
Omar Abdel-Rahman
Avicenna Oncology Center
Position Title
Consultant and lecturer
About this CDAS Project
PLCO (Learn more about this study)
Project ID
Initial CDAS Request Approval
Oct 4, 2018
Interaction of family history, physical activity and environmental factors in the risk for the development of prostate cancer
A number of factors have been linked to the risk of developing prostate cancer, including positive family history, lack of exercise, higher body mass index and metabolic syndrome. The current project aims to analyse the extent of interaction of these factors in the formulation of prostate cancer risk. Moreover, it aims to determine if risk factors for low grade prostate cancer are different from those predisposing to high grade prostate cancer. The current project might lead to a deeper understanding of the development of different subtypes of prostate cancer. Thus, it might impact our screening/ prevention strategies for this disease in the future.

1. To clarify the extent of interaction of family history with other physical environmental risk factors in the development of prostate cancer.
2. To clarify if risk factors for lower grade prostate cancer are different from or similar to risk factors for high grade prostate cancer.
3. To clarify if prostate cancer screening strategies can be more personalized according to baseline risk factors of different patient subgroups.


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