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Genomic Variation and Risk of Breast, Prostate, Lung and Colorectal Cancers: a Kin-Cohort Study within CGEMS

Principal Investigator
Name
Mark Purdue
Institution
NCI, DCEG, OEEB
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
2007-0033
Initial CDAS Request Approval
Jun 12, 2007
Title
Genomic Variation and Risk of Breast, Prostate, Lung and Colorectal Cancers: a Kin-Cohort Study within CGEMS
Summary
The recently completed Cancer Genetic Markers of Susceptibility (CGEMS) whole-genome scan of prostate cancer characterized approximately 550,000 SNPs for 1120 cases and 1132 controls selected from the PLCO Trial. Information on the CGEMS participants' family structure and family history of cancer was also collected on the PLCO baseline questionnaire. Using the kin-cohort method, we propose to exploit these genetic and family history data to conduct genome-wide association studies of cancer among the first-degree relatives of CGEMS participants. Our immediate objective is to conduct investigations for the four most common cancer types (breast, prostate, colorectal and lung cancers). If this initial project yields promising results, we will expand our kin-cohort investigations to include rarer cancers and to the data from the CGEMS whole-genome scan of breast cancer being conducted in the Nurses Health Study.
Aims

The primary aim of our proposal is to construct a kin-cohort study for conducting dense genome-wide scans among first-degree relatives of the CGEMS prostate scan participants to identify susceptibility loci for the four most common cancer types (prostate, breast, colon/rectum and lung). More generally, we seek to investigate whether kin-cohort studies constructed from whole-genome scans can provide useful additional information in identifying genomic regions associated with cancer risk.

Collaborators

Nilanjan Chatterjee (BB / DCEG / NCI)
Patricia Hartge (OD / DCCPS / NCI)
Shalom Wacholder (BB / DCEG / NCI)
Meredith Yeager (CGF / ATC / NCI)

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