Analysis of Baseline Exam in ACF Study

Principal Investigator

Name
Paul Pinsky

Institution
NCI, DCP, EDRG

Email
pinskyp@mail.nih.gov

About this CDAS Project

Study
PLCO (Learn more about this study)

Project ID
2007-0022

Initial CDAS Request Approval
Apr 26, 2007

Title
Analysis of Baseline Exam in ACF Study

Summary
Provide a brief abstract of 300 words or less. Aberrant crypt foci (ACF) are possible precursors of adenomas and colorectal cancers. Estimate of the prevalence of ACF vary widely. This study examines the prevalence of endoscopic ACF, risk factors for ACF, and the concordance of endoscopic and histologic ACF

Aims

Specific Aim 1: To describe endoscopic findings on initial ACF exam 2. To describe histologic findings of initial ACF exam by endoscopic category. 3. To correlate endoscopic and histologic findings with baseline covariates.

Collaborators

Matt Mutch (Washington University)
Robert Schoen (Pittsburgh)

Related Publications

• A multicenter study of prevalence and risk factors for aberrant crypt foci.
  Mutch MG, Schoen RE, Fleshman JW, Rall CJ, Dry S, Seligson D, Charabaty A, Chia D, Umar A, Viner J, Hawk E, Pinsky PF
  Clin. Gastroenterol. Hepatol. 2009 May; Volume 7 (Issue 5): Pages 568-74 PUBMED