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Questionnaire Risk Factors and Multiple Disease Outcomes in PLCO

Principal Investigator
Name
Wen-Yi Huang
Institution
NCI, DCEG, OEEB
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
2006-0321
Initial CDAS Request Approval
Jul 1, 2006
Title
Questionnaire Risk Factors and Multiple Disease Outcomes in PLCO
Summary
Cohort studies, such as PLCO, provide an opportunity to evaluate a risk factor, or combinations of risk factors, in relation to multiple disease outcomes. This is important for evaluating the overall public health impact of lifestyle and dietary risk factors which can affect multiple organ systems and diseases. Recent epidemiologic studies have taken this approach for study of health risks associated with obesity. A study among 362,552 Swedish men showed that obese men had a significantly increased risk of all cancers combined; risks were most pronounced for esophageal adenocarcinoma, renal cell carcinoma, malignant melanoma, and cancers of the colon, rectum, and liver1. Among 527,265 U.S. men and women in the National Institutes of Health-AAPR cohort, excess body weight during midlife was associated with an increased risk of death; most notably, among healthy people who had never smoked, risk of death increased by 20 to 40 percent among overweight persons and by two to at least 3 times among obese persons2.
Aims

To evaluate relations between questionnaire risk factors and various cancer and death outcomes.

Collaborators

Jiyoung Ahn (NEB/DCEG)
Jocelyn Weiss (OEEB/DCEG)
Joel Weissfeld (University oF Pittsburgh)
Paul Pinsky (DCP/NCI)
Rashmi Sinha (NEB/DCEG)
Sonja Berndt (OEEB/DCEG)
Wen-Yi Huang (OEEB/DCEG)
Amy Berrington de Gonzalez (REB/DCEG)

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