Meat and meat mutagens and risk of breast cancer in the PLCO Cancer Screening Trial
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
2007-0055
Initial CDAS Request Approval
Feb 15, 2008
Title
Meat and meat mutagens and risk of breast cancer in the PLCO Cancer Screening Trial
Summary
Prospectively examine associations between meat type, meat mutagens (i.e. heterocyclic amines) and iron intake and breast cancer using the PLCO dietary history questionnaire (DHQ) detailed meat-cooking module. We hypothesize that red meat, meat-mutagens and heme iron intake will be positively associated with breast cancer risk.
Aims
1. To prospectively examine the relationship between meat type, meat cooking methods, and meat-mutagens (i.e. heterocyclic amines) and the risk for breast cancer. 2. To examine the association between breast cancer incidence and iron intake (heme iron and total iron). We hypothesize that red meat, meat-mutagens (i.e. heterocyclic amines) and heme iron intake will be positively associated with breast cancer risk.
Collaborators
Amanda Cross (NEB/DCEG/NCI)
Barry Graubard (BB/DCEG/NCI)
Rashmi Sinha (NEB/DCEG/NCI)
Related Publications
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Intake of meat, meat mutagens, and iron and the risk of breast cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
Ferrucci LM, Cross AJ, Graubard BI, Brinton LA, McCarty CA, Ziegler RG, Ma X, Mayne ST, Sinha R
Br. J. Cancer. 2009 Jul; Volume 101 (Issue 1): Pages 178-84 PUBMED