Genetic ancestry of African Americans who have been already genotyped in PLCO
Principal Investigator
Name
Neal Freedman
Degrees
PhD, MPH
Institution
NCI
Position Title
Senior Investigator
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-263
Initial CDAS Request Approval
Mar 1, 2017
Title
Genetic ancestry of African Americans who have been already genotyped in PLCO
Summary
We are conducting a study of individuals with varying degrees of African ancestry, including East Africans, West Africans, Africans from the Caribbean, African-Americans, Brazilians, etc. in order to determine the African diaspora across much of the globe. There are a number of PLCO subjects that were genotyped at CGR in various GWAS that were subsequently determined to have significant African ancestry (determined genetically, approximately 500 of them) and therefore excluded from GWAS analyses of Europeans and Asians. We would also like to ask that we are provided birth year for the subjects so we can calibrate likely admixture dates for each subject. This project will ultimately be published and is using thousands of individuals from both publicly-available sources and through collaborations with other academic investigators.
Aims
We would like to determine genetic admixture of African Americans in PLCO using already generated GWAS data.
Collaborators
Meredith Yeager, Cancer Genomics Research Laboratory, NCI: yeagerm@mail.nih.gov