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Principal Investigator
Name
David Christiani
Degrees
MPH, MS, MD
Institution
Harvard University
Position Title
Professor
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-208
Initial CDAS Request Approval
Apr 26, 2016
Title
A genome-wide survival analysis of non-small cell lung cancers
Summary
Lung cancer, especially non-small cell lung cancer (NSCLC), is the leading cause of cancer-related deaths all over the world. Individual variation in genetic background may influence treatments and clinical outcomes of NSCLC patients. To better understand the effects of molecular biomarkers, we are going to conduct a genome-wide analysis to investigate the prognostic implications of genetic variants in NSCLC patients. We will perform single nucleotide polymorphism (SNP)-based and gene-based analysis using multivariate logistic regression model and multivariate logistic kernel machine, respectively. Meta-analysis will be adopted to improve statistical power by integrating samples from Harvard School of Public Health (HSPH) and PLCO.
Aims

To identify NSCLC survival risk associated SNPs or genes.

Collaborators

Ruyang Zhang, Harvard School of Public Health
Yongyue Wei, Harvard School of Public Health
Zhaoxi Wang, Harvard School of Public Health

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