Early Phase Prevention Trials Publications
Here you can browse the complete list of publications for Early Phase Prevention Trials
| Title | PubMed | Authors | Journal | Year | Studies |
|---|---|---|---|---|---|
| A randomized Phase I pre-operative window trial of transdermal endoxifen in women planning mastectomy: Evaluation of dermal safety, intra-mammary drug distribution, and biologic effects. | 38171245 | Lee O , Bazzi LA , Xu Y , Pearson E , Wang M , Hosseini O , Akasha AM , Choi JN , Karlan S , Pilewskie M , Kocherginsky M , Benante K , Helland T , Mellgren G , Dimond E , Perloff M , Heckman-Stoddard BM , Khan SA | Biomed Pharmacother | 2024 | EPPT |
| Epidermal Growth Factor Receptor Inhibition With Erlotinib in Liver: Dose De-Escalation Pilot Trial as an Initial Step in a Chemoprevention Strategy | Tanabe, K. K., Zahrieh, D., Strand, C. A., Hoshida, Y., Flotte, T. J., Della’Zanna, G., Umar, A., Chavin, K. D., Cleary, S., Kubota, N., Llovet, J. M., Patel, T., Siegel, C., & Limburg, P. J. | Gastro Hep Advances | 2024 | EPPT | |
| Phase I Dose Escalation Study of Topical Bexarotene in Women at High Risk for Breast Cancer | Parijatham S. Thomas, Anisha B. Patel, J. Jack Lee, Diane D. Liu, Mike Hernandez, Miguel Muzzio, Alejandro Contreras, Valerie Sepeda, Carrie Mays, Diane Weber, Lana A. Vornik, Seema A. Khan, Eileen Dimond, Brandy M. Heckman-Stoddard, Marjorie Perlof… | Cancer Prev Res | 2023 | EPPT | |
| Phase Ib trial of inhaled iloprost for the prevention of lung cancer with predictive and response biomarker assessment | Miller YE, Ghosh M, Merrick DT, Kubala B, Szabo E, Bengtson L, Kocherginsky M, Helenowski IB, Benante K, Schering T, Kim J, Kim H, Ha D, Bergan RC, Khan SA and Keith RL | Front. Oncol. | 2023 | EPPT | |
| Presurgical Oral Tamoxifen vs Transdermal 4-Hydroxytamoxifen in Women With Ductal Carcinoma In Situ: A Randomized Clinical Trial. | 37870954 | Khan SA , Mi X , Xu Y , Blanco LZ , Akasha AM , Pilewskie M , Degnim AC , AlHilli Z , Amin AL , Hwang ES , Guenther JM , Kocherginsky M , Benante K , Zhang S , Helland T , Hustad SS , Gursel DB , Mellgren G , Dimond E , Perloff M , Heckman-Stoddard … | JAMA Surg | 2023 | EPPT |
| Efficacy of Alternative Dose Regimens of Exemestane in Postmenopausal Women With Stage 0 to II Estrogen Receptor-Positive Breast Cancer: A Randomized Clinical Trial. | 36951827 | Serrano D , Gandini S , Thomas P , Crew KD , Kumar NB , Vornik LA , Lee JJ , Veronesi P , Viale G , Guerrieri-Gonzaga A , Lazzeroni M , Johansson H , D'Amico M , Guasone F , Spinaci S , Bertelsen BE , Mellgren G , Bedrosian I , Weber D , Castile T ,… | JAMA Oncol | 2023 | EPPT |
| Clinical Study of Aspirin and Zileuton on Biomarkers of Tobacco-Related Carcinogenesis in Current Smokers. | 35740559 | Garland LL, Guillen-Rodriguez J, Hsu CH, Davis LE, Szabo E, Husted CR, Liu H, LeClerc A, Alekseyev YO, Liu G, Bauman JE, Spira AE, Beane J, Wojtowicz M, Chow HS | Cancers (Basel) | 2022 | EPPT |
| Phase II trial of weekly erlotinib dosing to reduce duodenal polyp burden associated with familial adenomatous polyposis. | 35636921 | Samadder NJ, Foster N, McMurray RP, Burke CA, Stoffel E, Kanth P, Das R, Cruz-Correa M, Vilar E, Mankaney G, Buttar N, Thirumurthi S, Turgeon DK, Sossenheimer M, Westover M, Richmond E, Umar A, Della'Zanna G, Rodriguez LM, Szabo E, Zahrieh D, Limbur… | Gut | 2022 | EPPT |
| Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers. | 35565256 | Bauman JE, Hsu CH, Centuori S, Guillen-Rodriguez J, Garland LL, Ho E, Padi M, Bageerathan V, Bengtson L, Wojtowicz M, Szabo E, Chow HS | Cancers (Basel) | 2022 | EPPT |
| A Phase 2, Double-blind, Randomized Controlled Trial of PROSTVAC in Prostate Cancer Patients on Active Surveillance. | 36517408 | Parsons JK , Pinto PA , Pavlovich CP , Uchio E , Nguyen MN , Kim HL , Gulley JL , Sater HA , Jamieson C , Hsu CH , Wojtowicz M , House M , Schlom J , Donahue RN , Dahut WL , Madan RA , Bailey S , Centuori S , Bauman JE , Parnes HL , Chow HS | Eur Urol Focus | 2022 | EPPT |
| A Randomized, Double-Blinded, Placebo-Controlled Trial of Simvastatin to Prevent Recurrent Pancreatitis. | 35195610 | Goodman MT , Lo SK , Yadav D , Wu BU , Jamil LH , Kwok KK , Papachristou GI , Afghani E , Choi-Kuaea Y , Waldron RT , Lombardi C , Jeon CY , Helenowski IB , Richmond E , Benante K , Habtezion A , Schering T , Khan SA , Rodriguez LM , Pandol SJ | Pancreas | 2022 | EPPT |
| A phase II randomized placebo-controlled trial of pomegranate fruit extract in men with localized prostate cancer undergoing active surveillance. | 33095939 | Jarrard D, Filon M, Huang W, Havighurst T, DeShong K, Kim K, Konety BR, Saltzstein D, Mukhtar H, Wollmer B, Suen C, House MG, Parnes HL, Bailey HH | Prostate | 2021 | EPPT |
| Local Transdermal Delivery of Telapristone Acetate Through Breast Skin, Compared With Oral Treatment: A Randomized Double-Blind, Placebo-Controlled Phase II Trial. | 32996592 | Lee O, Pilewskie M, Karlan S, Tull MB, Benante K, Xu Y, Blanco L, Helenowski I, Kocherginsky M, Yadav S, Hosseini O, Hansen N, Bethke K, Muzzio M, Troester MA, Dimond E, Perloff M, Heckman-Stoddard B, Khan SA | Clin Pharmacol Ther | 2021 | EPPT |
| Inhibition of mTOR signaling and clinical activity of metformin in oral premalignant lesions. | 34255745 | Gutkind JS, Molinolo AA, Wu X, Wang Z, Nachmanson D, Harismendy O, Alexandrov LB, Wuertz BR, Ondrey FG, Laronde D, Rock LD, Rosin M, Coffey C, Butler VD, Bengtson L, Hsu CH, Bauman JE, Hewitt SM, Cohen EE, Chow HS, Lippman SM, Szabo E | JCI Insight | 2021 | EPPT |
| Vadis trial: Phase II trial of nelipepimut-s peptide vaccine in women with DCIS of the breast | Anne E O'Shea; Guy T Clifton; Na Qiao; Brandy Heckman-Stoddard; Malgorzata Wojtowicz; Eileen Dimond; Isabelle Bedrosian; Diane Weber; Alex Husband; Ricardo Pastorello; Lana Vornik; George Peoples; Elizabeth A Mittendorf | Cancer Res | 2021 | EPPT | |
| Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa. | 32641470 | Reyes-Uribe L, Wu W, Gelincik O, Bommi PV, Francisco-Cruz A, Solis LM, Lynch PM, Lim R, Stoffel EM, Kanth P, Samadder NJ, Mork ME, Taggart MW, Milne GL, Marnett LJ, Vornik L, Liu DD, Revuelta M, Chang K, You YN, Kopelovich L, Wistuba II, Lee JJ, Sei… | Gut | 2020 | EPPT |
| Low-Dose Aspirin in High-Risk Individuals With Screen-Detected Subsolid Lung Nodules: A Randomized Phase II Trial. | 33409459 | Bonanni B, Serrano D, Maisonneuve P, Veronesi G, Johansson H, Aristarco V, Varricchio C, Cazzaniga M, Lazzeroni M, Rampinelli C, Bellomi M, Vecchi M, Spaggiari L, Vornik L, Brown PH, Beavers T, Guerrieri-Gonzaga A, Szabo E | JNCI Cancer Spectr | 2020 | EPPT |
| Effect of Intermittent Versus Continuous Low-Dose Aspirin on Nasal Epithelium Gene Expression in Current Smokers: A Randomized, Double-Blinded Trial. | 31451521 | Garland LL, Guillen-Rodriguez J, Hsu CH, Yozwiak M, Zhang HH, Alberts DS, Davis LE, Szabo E, Merenstein C, Lel J, Zhang X, Liu H, Liu G, Spira AE, Beane JE, Wojtowicz M, Chow HS | Cancer Prev Res (Phila) | 2019 | EPPT |
| A Randomized, Placebo-Controlled, Double-Blind, Dose Escalation, Single Dose, and Steady-State Pharmacokinetic Study of 9cUAB30 in Healthy Volunteers. | 31484659 | Kolesar JM, Andrews S, Green H, Havighurst TC, Wollmer BW, DeShong K, Laux DE, Krontiras H, Muccio DD, Kim K, Grubbs CJ, House MG, Parnes HL, Heckman-Stoddard BM, Bailey HH | Cancer Prev Res (Phila) | 2019 | EPPT |
| A Phase I Trial of Berberine in Chinese with Ulcerative Colitis. | 31619442 | Xu L, Zhang Y, Xue X, Liu J, Li ZS, Yang GY, Song Y, Pan Y, Ma Y, Hu S, Wen A, Jia Y, Rodriguez LM, Tull MB, Benante K, Khan SA, Cao Y, Jovanovic B, Richmond E, Umar A, Bergan R, Wu K | Cancer Prev Res (Phila) | 2019 | EPPT |