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The Mayo Lung Project was a two arm randomized screening study designed to test if lung cancer mortality rates could be reduced through the use of periodic screenings. The intervention arm was offered a chest x-ray and sputum cytology every four months for six years while the usual care arm was advised at trial entry to receive the same tests annually. Extended follow-up was conducted through 1996. The study concluded that there was not a lung cancer mortality reduction for the intervention arm.

Study Years: 1971-1983

Randomized trial with two arms:

  • Arms
    • Arm I: Usual Care
    • Arm II: Intervention Screening (chest x-ray and sputum cytology)

Study Eligibility:
  • Ages Eligible for Study: 45-80
  • Sexes Eligible for Study: Male
  • Recruited from Mayo Clinic outpatients
  • Without known lung cancer
  • Smokers of at least one pack of cigarettes per day
  • Expected life expectancy of 5 or more years
  • Respiratory reserve adequate to undergo lobectomy