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Investigation of Prostate Cancer Risk Factors and Targeted Screening

Principal Investigator
Name
Amanda Black
Institution
NCI, DCEG, EBP
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
2009-0243
Initial CDAS Request Approval
Nov 4, 2009
Title
Investigation of Prostate Cancer Risk Factors and Targeted Screening
Summary
PLCO has recently demonstrated an increased rate of prostate cancer incidence in the screened arm (with no mortality reduction) despite the relatively high level of contamination in the control arm. It is possible that this overdiagnosis of prostate cancer in the screened arm might attenuate the risk estimates of factors associated with prostate cancer incidence. Further, despite the recently published 'conflicting' results and the variety of recommendations, there is a general consensus that men with a life expectancy of <7-10 years should not be screened for prostate cancer. However, although PSA screening may be of limited value in the general population, it may be possible to identify a suitable sub-population of men to target prostate cancer screening.
Aims

Aim 1: To compare the risk estimates of factors associated with prostate cancer incidence and mortality between the two trial arms. Aim 2: Compare the incidence rates of prostate cancer, aggressive prostate cancer and prostate cancer specific mortality between the two arms for each cohort of men. 1. men with 0 co-morbidities (reported on BQX) 2. men with 1 co-morbidity (reported on the BQX) 3. men with >=2 co-morbidities (reported on the BQX) 4. men with no family history of prostate cancer (reported on BQX) 5. men with one affected first degree relative (reported on BQX) 6. men with more than one affected relative (reported on BQX) 7. men with no family history of any cancer (reported on BQX) 8. men with any family history of any cancer (reported on BQX).

Collaborators

Anthony D’Amico (Harvard)
Gerry Andriole (Wash U)
Phil Castle (DCEG, NCI)
Paul Doria-Rose (DCP, NCI)
Robert Grubb (Wash U)
Grant Izmirlian (DCP, NCI)
Lawrence Ragard (Westat)
Ming Chen (UConn)
Paul Pinsky (DCP, NCI)

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