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Inflammation and Sex Hormones in Relation to Prostate Cancer Risk

Principal Investigator
Name
Ann Hsing
Institution
NCI, DCEG, HREB
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
2007-0046
Initial CDAS Request Approval
Oct 15, 2007
Title
Inflammation and Sex Hormones in Relation to Prostate Cancer Risk
Summary
Accumulating data suggests a possible link between inflammation and prostate cancer risk and the possible interplay of the inflammation and hormonal pathways in prostate cancer etiology. The proposed value-added study sets out to investigate the role of inflammation genes in prostate cancer, individually as well as in conjunction with variants in hormone-related genes and serum hormones levels. In addition, to provide biological insight into potential etiologic mechanisms, we will assess the relationship between serum levels of sex hormones and variants in inflammation genes.
Aims

1. Provide an initial examination of the role of inflammation genes in prostate cancer through haplotype and pathway analyses, using single nucleotide polymorphism (SNP) data in about 783 genes in the inflammation pathway already genotyped in CGEMS (Appendix A). This aim will be carried out jointly with investigators from 2 other inflammation-related proposals (PIs: W-Y Huang and H-L Wong). 2. Determine the joint effects of a) inflammation genes and serum levels of sex hormones on prostate cancer risk, b) inflammation genes and 34 selected sex hormone-related genes (Table 1) on prostate cancer risk, and c) inflammation genes and 8q24 risk variants on prostate cancer risk 3. Determine the genotype-phenotype correlations of inflammation genes with serum sex hormone levels in the control population.

Collaborators

Anand Chokkalingam (University of California, Berkley)
Stephen Chanock (CCR & DCEG, NCI, NIH)
Lisa Chu (DCP, NCI, NIH)
Richard Hayes (OEEB, DCEG, NCI, NIH)
Wen-Yi Huang (OEEB, DCEG, NCI, NIH)
Idan Menashe (BB, DCEG, NCI, NIH)
Sabah Quraishi (HREB, DCEG, HCI, NIH)
Philip Rosenberg (BB, DCEG, NCI, NIH)
Kai Yu (BB, DCEG, NCI, NIH)