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Initial CDAS Request Approval
Jul 1, 2006
Prostate Cancer Other Factors-Family History
Having a familial antecedent of prostate cancer is a risk factor for prostate cancer. Some studies reveal differential characteristics between the prostate cancer cases with and without a familial history of prostate cancer. E.g.: most studies show a younger age of diagnosis among prostate cancer cases with a familial antecedent than among those without. However, to date, the two studies that are population-based, do not support that observation. Data reporting differences in the magnitude of the risk among different ethnic groups is also scarce. Also, the impact of pre-diagnosis prostate cancer screening in the magnitude of the association has not been evaluated. In addition, answers to the questions above might help to design studies aimed to identify genes associated with prostate cancer.
The goal of this study is to investigate the association between family history of prostate cancer and which factors might influence such association. We will compare the incidence of prostate cancer among those with and without familial history of prostate, ovarian, colon and lung cancer at the moment of enrollment in the PLCO Trial. Multivariate analyses will be conducted using a Cox's proportional hazards model.