Life years gained by screening in the NLST

Principal Investigator

Name
Hormuzd Katki

Degrees
PhD

Institution
National Cancer Institute

Position Title
Senior Investigator

Email
katkih@mail.nih.gov

About this CDAS Project

Study
NLST (Learn more about this study)

Project ID
NLST-364

Initial CDAS Request Approval
Oct 23, 2017

Title
Life years gained by screening in the NLST

Summary
We would like to analyze the life years gained from CT screening in the CT arm of the NLST.

Aims

We will build a mortality model in the X-ray arm of the NLST and use it to predict, for each individual in the CT arm, their expected life without CT screening (truncated at Jan 15, 2009). We will then subtract this from their observed life (truncated at Jan 15, 2009) to get the distribution for the model-enhanced life years gained from screening in the CT arm. Because life years gained is on the order of weeks, we would need at least the month and year of randomization to obtain a fairly accurate estimate of the distribution.

Collaborators

Anil Chaturvedi
Chris Berg
Li Cheung

Related Publications

• Absolute lung cancer risk increases among individuals with >15 quit-years: Analyses to inform the update of the American Cancer Society lung cancer screening guidelines.
  Landy R, Cheung LC, Young CD, Chaturvedi AK, Katki HA
  Cancer. 2023 Nov 1 PUBMED
• Management of Lung Cancer Screening Results Based on Individual Prediction of Current and Future Lung Cancer Risks.
  Robbins HA, Cheung LC, Chaturvedi AK, Baldwin DR, Berg CD, Katki HA
  J Thorac Oncol. 2021 Oct 11 PUBMED