The natural history of aberrant crypt foci.
Schoen RE, Mutch M, Rall C, Dry SM, Seligson D, Umar A, Pinsky P
BACKGROUND: Aberrant crypt foci (ACF) are the putative precursors to colorectal adenomas and may be useful as biomarkers. Knowledge of their natural history is essential to understanding their potential utility.
OBJECTIVE: Our purpose was to examine ACF detection 1 year after initial observation.
DESIGN: We conducted a multicenter study of ACF by using a standardized protocol. ACF in the rectum were assessed and subjects returned 1 year later to evaluate the natural history of the lesions.
SETTING: Ancillary study to the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
RESULTS: Of 78 subjects enrolled, 64 (82%) returned for a repeat examination 1 year later. The mean age was 71 years, 70% were male, and 54% had a history of adenomatous polyps. At the initial examination, 66% of subjects had at least 1 ACF detected in the rectum, with a mean of 2.1 +/- 2.3 per person. One year later, 60% of these subjects had at least 1 of the original ACF reidentified, but only 43% of all ACF were reidentified. A total of 56% of subjects had new ACF identified.
LIMITATIONS: These results are generated from the pilot phase. Improvements or change in technique over time could have influenced the results.
CONCLUSIONS: A total of 60% of subjects who had ACF continued to have at least one ACF 1 year later, but less than half the specific ACF could be reidentified, and more than 50% of subjects had new ACF. These results imply a considerable dynamic to ACF detection over a 1-year period of observation.
- 2007-0021: Analysis of Natural History of ACF using ACF Pilot Study Data (Paul Pinsky - 2007)