Skip to Main Content

An official website of the United States government

Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at OPM.gov.

Genetic variants in frizzled-related protein (FRZB) and the risk of colorectal neoplasia.

About this Publication
Title
Genetic variants in frizzled-related protein (FRZB) and the risk of colorectal neoplasia.
Pubmed ID
19067193 (View this publication on the PubMed website)
Publication
Cancer Causes Control. 2009 May; Volume 20 (Issue 4): Pages 487-90
Authors
Berndt SI, Huang WY, Yeager M, Weissfeld JL, Chanock SJ, Hayes RB
Affiliations
  • Division of Cancer Epidemiology & Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 8116, MSC 7240, Bethesda, MD 20892-7240, USA. berndts@mail.nih.gov
Abstract

OBJECTIVE: The Wnt/APC/beta-catenin signaling pathway, which includes frizzled-related protein (FRZB), plays a critical role in the development of colorectal cancer, and recent evidence suggests that the functional polymorphism, FRZB Arg324Gly, may be associated with risk for this disease. To determine if this finding could be replicated, we investigated the association between two FRZB polymorphisms (Arg324Gly and Arg200Trp) and the risk of colorectal adenoma and cancer in nested case-control studies.

METHODS: Participants consisted of 1,709 adenoma cases, 620 cancer cases, and 1,849 controls within the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CI) for the associations with colorectal neoplasia.

RESULTS: No association was observed for either polymorphism or any haplotypes with colorectal adenoma or colorectal cancer (p>0.05 for all).

CONCLUSION: Our study does not support the previously observed association between the FRZB 324Gly variant and colorectal cancer risk. However, further study of additional genetic variants within this pathway is still warranted, given the important role of the Wnt signaling pathway in colorectal carcinogenesis.

Related CDAS Studies
Related CDAS Projects