Skip to Main Content

An official website of the United States government

Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at OPM.gov.

About this Publication
Title
Positive associations between dietary potential acid load and renal cancer incidence and mortality: Results from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening trial.
Pubmed ID
39689651 (View this publication on the PubMed website)
Digital Object Identifier
Publication
Public Health. 2024 Dec 16; Volume 238: Pages 229-238
Authors
Ren X, Deng S, Xiang L, Gu H, Tang Y, Wang Y, Tong S, Peng L, Liu D
Affiliations
  • Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Department of Clinical Nutrition, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Department of Clinical Nutrition, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address: tswcqmu@cqmu.edu.cn.
  • Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address: penglinglong_cqmu@cqmu.edu.cn.
  • Department of Gastrointestinal Surgery, Chongqing Jiulongpo People's Hospital, Chongqing, China; Department of General Surgery, Xipeng Town Health Center of Jiulongpo District, Chongqing, China. Electronic address: 932721020@qq.com.
Abstract

OBJECTIVES: To explore the relationships between dietary potential acid load and renal cancer (RC) incidence and mortality.

STUDY DESIGN: A prospective cohort study involving 97,166 U S. adults aged 55-74 years.

METHODS: Data utilized in this study were drawn from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO). Dietary potential acid load was assessed by dietary acid load (DAL), potential renal acid load (PRAL) and net endogenous acid production (NEAP) scores using a validated Diet History Questionnaire (DHQ). Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) for RC incidence and mortality with adjustment for potential confounders. Restricted cubic spline (RCS) plots were utilized to reveal whether there were nonlinear associations between the DAL, PRAL, and NEAP scores and RC incidence and mortality.

RESULTS: During a follow-up period of 859,907 and 1,467,573 person-years, 423 RC cases and 221 mortality cases were documented. DAL, PRAL, and NEAP scores were positively associated with RC incidence (DAL: HR 1.41; 95% CI 1.05, 1.90; P-trend = 0.010; PRAL: HR 1.45; 95% CI 1.10, 1.91; P-trend = 0.010; NEAP: HR 1.39; 95% CI 1.04, 1.85; P-trend = 0.029). Similar associations were observed between DAL, PRAL, and NEAP scores and RC mortality. The RCS plots demonstrated a nonlinear association between DAL score and RC risk, while a linear association was observed between DAL score and RC mortality. Similar linear associations were found between PRAL and NEAP scores and RC incidence and mortality.

CONCLUSION: A higher dietary potential acid load was associated with higher risk of RC incidence and mortality in American adults.

Related CDAS Studies