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Genome-wide association study identifies tumor anatomical site-specific risk variants for colorectal cancer survival.

About this Publication
Title
Genome-wide association study identifies tumor anatomical site-specific risk variants for colorectal cancer survival.
Pubmed ID
34996992 (View this publication on the PubMed website)
Digital Object Identifier
Publication
Sci Rep. 2022 Jan 7; Volume 12 (Issue 1): Pages 127
Authors
Labadie JD , Savas S , Harrison TA , Banbury B , Huang Y , Buchanan DD , Campbell PT , Gallinger SJ , Giles GG , Gunter MJ , Hoffmeister M , Hsu L , Jenkins MA , Lin Y , Ogino S , Phipps AI , Slattery ML , Steinfelder RS , Sun W , Van Guelpen B , ...show more Hua X , Figuieredo JC , Pai RK , Nassir R , Qi L , Chan AT , Peters U , Newcomb PA
Affiliations
  • Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Discipline of Genetics, Faculty of Medicine, Memorial University, St. John's, NL, Canada.
  • Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
  • Department of Population Science, American Cancer Society, Atlanta, GA, USA.
  • Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
  • Nutrition and Metabolism Section, International Agency for Research On Cancer, World Health Organization, Lyon, France.
  • Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Program in Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.
  • Department of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.
...show more
  • Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
  • Department of Pathology, School of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
  • Department of Public Health Sciences, University of California Davis, Davis, CA, USA.
  • Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. pnewcomb@fredhutch.org.
Abstract

Identification of new genetic markers may improve the prediction of colorectal cancer prognosis. Our objective was to examine genome-wide associations of germline genetic variants with disease-specific survival in an analysis of 16,964 cases of colorectal cancer. We analyzed genotype and colorectal cancer-specific survival data from a consortium of 15 studies. Approximately 7.5 million SNPs were examined under the log-additive model using Cox proportional hazards models, adjusting for clinical factors and principal components. Additionally, we ran secondary analyses stratifying by tumor site and disease stage. We used a genome-wide p-value threshold of 5 × 10-8 to assess statistical significance. No variants were statistically significantly associated with disease-specific survival in the full case analysis or in the stage-stratified analyses. Three SNPs were statistically significantly associated with disease-specific survival for cases with tumors located in the distal colon (rs698022, HR = 1.48, CI 1.30-1.69, p = 8.47 × 10-9) and the proximal colon (rs189655236, HR = 2.14, 95% CI 1.65-2.77, p = 9.19 × 10-9 and rs144717887, HR = 2.01, 95% CI 1.57-2.58, p = 3.14 × 10-8), whereas no associations were detected for rectal tumors. Findings from this large genome-wide association study highlight the potential for anatomical-site-stratified genome-wide studies to identify germline genetic risk variants associated with colorectal cancer-specific survival. Larger sample sizes and further replication efforts are needed to more fully interpret these findings.

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