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Prediagnostic Antibody Responses to Fusobacterium nucleatum Proteins Are Not Associated with Risk of Colorectal Cancer in a Large U.S. Consortium.

Authors

Lo CH, Blot WJ, Teras LR, Visvanathan K, Le Marchand L, Haiman CA, Chen Y, Sesso HD, Wassertheil-Smoller S, Tinker LF, Peek RM, Potter JD, Cover TL, Zeleniuch-Jacquotte A, Berndt SI, Waterboer T, Epplein M, Butt J, Song M

Affiliations

  • Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
  • Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee.
  • Department of Population Science, American Cancer Society, Atlanta, Georgia.
  • Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
  • Population Sciences in the Pacific Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
  • University of Southern California Keck School of Medicine and University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California.
  • Department of Population Health, New York University School of Medicine, New York, New York.
  • Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
  • Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York.
  • Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
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  • Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
  • Centre for Public Health Research, Massey University, Wellington, New Zealand.
  • Department of Medicine and Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center and Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee.
  • Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, NIH, Rockville, Maryland.
  • Infections and Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
  • Cancer Control and Population Sciences Program, Duke Cancer Institute and Department of Population Health Sciences, Duke University, Durham, North Carolina.
  • Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. msong@hsph.harvard.edu.

Abstract

BACKGROUND: The association between prediagnostic antibody responses to Fusobacterium nucleatum (F. nucleatum) and subsequent risk of colorectal cancer is not established.

METHODS: We conducted a nested case-control study of 8,126 participants in a consortium of 10 prospective cohorts in the United States.

RESULTS: Higher seroprevalence of any F. nucleatum antibody was observed among non-White participants (51.1%) compared with White participants (31.2%). We did not find any statistically significant association between seropositivity to any of the eight F. nucleatum proteins and colorectal cancer risk.

CONCLUSIONS: Prediagnostic antibody responses to F. nucleatum proteins were not associated with the risk of colorectal cancer.

IMPACT: Future studies may consider a more specific detection of the immunoglobulin isotypes or focus on examining F. nucleatum in stool or tissue samples.

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Publication Details

PubMed ID
33737297

Digital Object Identifier
10.1158/1055-9965.EPI-20-1471

Publication
Cancer Epidemiol Biomarkers Prev. 2021 Jun; Volume 30 (Issue 6): Pages 1279-1282

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