The Lung Screening Study (LSS) was a pilot study designed to assess the feasibility of conducting a large scale randomized controlled trial (RCT) of low radiation dose spiral computed tomography (LDCT) versus chest X-ray (CXR) for lung cancer screening.
During the fall of 2000, six PLCO screening centers recruited a total of 3,318 heavy or long-term smokers who were not participants in the PLCO trial and randomized them to receive either a screening LDCT scan (1,660 participants) or screening posteroanterior view chest radiograph (CXR) [1,658 participants].
The results of the LSS demonstrated convincingly the feasibility of an RCT of LDCT scanning in the United States.
Learn About LSS
Get a detailed description of the trial, explaining how and what data were collected. The main findings of the trial and counts of cancers are available as well.
Learn More about LSS
Available Datasets
Get detailed documentation of the Learn About LSS data available on this website, including data dictionaries.
LSS DatasetsSubmit a LSS Project Proposal
To gain access to available LSS datasets, you must submit a project proposal. These are reviewed by NCI. If your project is approved, you will be required to complete a Data Transfer Agreement (and a Material Transfer Agreement, if applicable) before you will be granted access.
Available Project Proposals
There is one type of LSS project. Click to begin a new project proposal.
Approved Projects
View approved projects that used LSS data. Project summaries, aims, collaborators and more are available.
Browse 4 ProjectsPublications
Browse the complete list of published articles on LSS data, including authors, journal names, and more.
Search 3 Publications